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Additionally, continued exposure of T cells at sites of inflammation elicits high levels of reactive oxygen species (ROS), which results decreased intracellular levels of GSH, dysregulation of redox balance, impaired signal transduction of the TCR/CD3 complex, and ultimately to synovial T cell hyporesponsiveness during RA [137]

High -tocopherol intakes, e.g., most vitamin E supplements, lead to increases in plasma -tocopherol, decreases in plasma -tocopherol (17), and increases in excretion of both -CEHC and -CEHC

Maintain a healthy microbial balance